Genetic Polymorphism of Angiotensin II Type 1 Receptors and Their Effect on the Clinical Outcome of Captopril Treatment in Arab Iraqi Patients with Acute Coronary Syndrome (Mid Euphrates)     

Fadhaa A. Ghafil  Bassim I. Mohammad  Hussain S. Al-Janabi  Najah R. Hadi  Hayder A. Al-Aubaidy 《Indian journal of clinical biochemistry : IJCB》2021,36(1):81

Genetic variation in the angiotensin II type 1 receptor (AT1R) has an important effect on the outcome of acute coronary syndrome (ACS) initiated treatment with captopril. This study aims to investigate the impact of genetic polymorphism of AT1R (rs5186 and rs275651) on the ACS outcome in Iraqi patients treated with captopril. A total of 250 Iraqi individuals with ACS were included in this case—control study and they were divided into two study groups; Study group 1 included 125 participants who were prescribed captopril, 25 mg twice daily and study group 2 included 125 participants who received no captopril as part of their ACS treatment (control study). The AT1R gene (rs5186) CC genotype was found to be associated with ST-elevation myocardial infarction (STEMI) (Odd’s ratio (O.R) = 1.2, P = 0.7), while AC was associated with Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) (O.R = 1.2, P = 0.8). AC genotype is more prone to have Percutaneous coronary intervention (PCI) after ACS attack (O.R = 1.2, P = 0.6). CC genotype had a risk to get less improvement (O.R = 1.6, P = 0.5), so might require higher doses of captopril during acute coronary insult. The AT1R gene (rs275651) AA genotype was associated with UA (O.R = 1.3, P = 0.9). AA and AT genotypes were more prone to have PCI after ACS attack (O.R = 3.9 P = 0.2, O.R = 3.5, P = 0.3 respectively) and thus requiring higher doses of captopril. We conclude that the AT1R rs5186, rs275651 genetic polymorphisms might partially affect the clinical outcome of ACS patients treated with captopril and might have captopril resistance which requires higher doses.  相似文献   

服务于乡村治理的民间武术组织转化路径研究     

张望龙 《河北体育学院学报》2020,34(5):86-90

自治、法治、德治“三治合一”的乡村治理体系，为探索民间武术组织服务于乡村治理提供了新思路。在传统社会，民间武术组织以武德传承强化乡村德治机制，以门规戒约规范乡村法治秩序，以家长制参与乡村自治实践。而进入现代社会，民间武术组织服务于乡村治理面临着传统德治弱化、法治建设不完善、参与自治机制不健全三方面的困境。提出，民间武术组织要建立新的道德体系，营造乡村治理的德治氛围；加强组织治理，强化乡村治理的法治理念；深化自治实践，主动承担乡村治理职责功能，旨在为更好促进民间武术组织有效治理、推动乡村发展提供参考。  相似文献   

基于动态分阶势场法的船舶自动避碰系统     

罗贤程  尹建川  李宏宾 《上海海事大学学报》2020,41(1):1-7

为使船舶在多船避让环境下适应航行环境的变化并自动复航,提出基于动态分阶势场法的船舶自动避碰系统。该系统基于动态势场避障规划算法,利用模糊综合评价法量化船舶碰撞危险度;依据《国际海上避碰规则》确定本船在不同会遇局面下的避让行动,并据此对斥力势函数进行调整。该系统将本船的避碰过程划分为航迹保持、避让和复航3个阶段,根据不同阶段的要求构建动态分阶势场;利用动态分阶势场法对船舶的航行环境进行建模,进而生成恰当的航向指令;利用自动舵产生舵角指令控制船舶完成避让、复航和航迹保持。仿真结果表明:该自动避碰系统可以引导船舶完成既定的避让行动,并能使船舶在安全会遇距离上驶过;该系统可以适应航行环境的变化,且具备航迹保持能力。  相似文献   

上海国际航运中心建设支持政策的量化评价     

张婕姝  陈靖瑶 《上海海事大学学报》2020,41(1):116-121

为增强上海国际航运中心建设支持政策的有效性,基于2009—2018年间国家及地方政府层面颁布的19个涉及上海国际航运中心建设的政策文本,应用文本挖掘方式提取评价指标,构建PMC指数模型对政策进行量化评价。分别选取3项针对性政策和3项辅助性政策作为评价对象进行实证分析,结果表明:针对性政策的PMC指数总得分高于辅助性政策的PMC指数总得分,且随着上海国际航运中心建设的不断推进,其引导作用不断加强;辅助性政策虽然只考虑到上海国际航运中心的部分建设需求,但在保障激励等方面给予了高度重视。  相似文献   

主客观信息融合的港口综合能源系统评价指标体系     

何大春  谈健  苏宜强  解翔  宋天立  蔡超  陈曦 《上海海事大学学报》2020,41(3):110-116

为建立绿色港口，实现港口的节能环保，对港口综合能源系统(port integrated energy system，PIES)的评价方法进行研究，提出一种主客观信息融合的PIES评价指标体系，将主观评价与数理统计模型进行结合，兼顾评价过程中的主客观因素，并采用基于马氏距离的统计检验方法对评分矩阵进行修正，实现对PIES的全面评价。通过青岛港董家口港区的调研数据，验证该方法的有效性。  相似文献   

唐代保辜制度对当代刑事和解制度的启示     

刘喆玉 《保定学院学报》2020,(3):36-42

保辜制度是我国古代一项极具特色的法律制度,在唐代臻于成熟。保辜制度的目的在于确定伤害行为与结果的因果关系,具有对受害人进行保护、对加害人赋予悔改机会以平稳修复社会关系的深层内涵,从某种意义上其与当代的刑事和解制度的目的有着一定的相通性,对于完善我国的刑事和解制度具有积极意义。借鉴唐代保辜制度理念,可以从扩大适用范围、增加审查起诉阶段观察期、加大司法机关参与力度、实行执行阶段保证人制度等方面完善我国刑事和解制度。  相似文献   

河北天生桥国家地质公园蜘蛛群落及多样性     

张保石  魏俊杰  滕忠才 《保定学院学报》2020,(3):109-113

2018年8月运用随机扫网、陷阱法和样方相结合的采集方法对河北天生桥国家地质公园蜘蛛种类和群落结构进行了调查,共获得1112头蜘蛛标本,隶属22科54属77种。采用群落多样性指数分析其多样性,结果阐明:天生桥国家地质公园蜘蛛具有丰富的物种多样性,不同植被环境中蜘蛛群落的组成结构有明显差别。灌木丛生境中蜘蛛物种丰富度、个体密度和多样性指数最高,具有稳定的群落结构;阔叶林中蜘蛛均匀度最高;针叶林和草甸中的物种丰富度和个体密度较低,优势度明显。植被保护对保护蜘蛛多样性具有重要意义。  相似文献   

An extension of the technology acceptance model in the big data analytics system implementation environment     

Surabhi Verma  Som Sekhar Bhattacharyya  Saurav Kumar 《Information processing & management》2018,54(5):791-806

Research on the adoption of systems for big data analytics has drawn enormous attention in Information Systems research. This study extends big data analytics adoption research by examining the effects of system characteristics on the attitude of managers towards the usage of big data analytics systems. A research model has been proposed in this study based on an extensive review of literature pertaining to the Technology Acceptance Model, with further validation by a survey of 150 big data analytics users. Results of this survey confirm that characteristics of the big data analytics system have significant direct and indirect effects on belief in the benefits of big data analytics systems and perceived usefulness, attitude and adoption. Moreover, there are mediation effects that exist among the system characteristics, benefits of big data analytics systems, perceived usefulness and the attitude towards using big data analytics system. This study expands the existing body of knowledge on the adoption of big data analytics systems, and benefits big data analytics providers and vendors while helping in the formulation of their business models.  相似文献   

Social network data to alleviate cold-start in recommender system: A systematic review     

Lesly Alejandra Gonzalez Camacho  Solange Nice Alves-Souza 《Information processing & management》2018,54(4):529-544

Recommender Systems are currently highly relevant for helping users deal with the information overload they suffer from the large volume of data on the web, and automatically suggest the most appropriate items that meet users needs. However, in cases in which a user is new to Recommender System, the system cannot recommend items that are relevant to her/him because of lack of previous information about the user and/or the user-item rating history that helps to determine the users preferences. This problem is known as cold-start, which remains open because it does not have a final solution. Social networks have been employed as a good source of information to determine users preferences to mitigate the cold-start problem. This paper presents the results of a Systematic Literature Review on Collaborative Filtering-based Recommender System that uses social network data to mitigate the cold-start problem. This Systematic Literature Review compiled the papers published between 2011–2017, to select the most recent studies in the area. Each selected paper was evaluated and classified according to the depth which social networks used to mitigate the cold-start problem. The final results show that there are several publications that use the information of the social networks within the Recommender System; however, few research papers currently use this data to mitigate the cold-start problem.  相似文献   

以推行“双证书”制为手段完善高职院校学生综合素质评价体系     

郭彬 《天津职业院校联合学报》2014,(2):13-15

为迎接新世纪的挑战和经济快速发展对技术技能型人才的需求，高职院校积极建立产学研一体化的办学理念和教学模式，全面加强对学生的素质教育，强化质量意识，以推行“双证书”制为手段完善学生综合素质评价体系。  相似文献